Human Chorionic Gonadotropin (HCG)

HCG - Human Chorionic Gonadotropin

What is Human Chorionic Gonadotropin?



Human Chorionic Gonadotropin (abbreviation: HCG) is not a steroid. It is a naturally occurring peptide hormone which in the early stages of pregnancy is produced by the embryo and later the production is taken over by the trophoblast (part of the placenta). Its main purpose is to control a pregnant womans hormones. Human chorionic gonadotropin supports the normal development of an egg in a woman's ovary, and stimulates the release of the egg during ovulation.

HCG binds to the same receptor and is molecularly similar to Leutenizing Hormone (LH) - a hormone which stimulates the leyding cells in male testes which then produce testosterone. Because of this similarity hCG is used to start testosterone production in the male testes or ovulation in the female ovaries.

HCG is a glycoprotein composed of 237 amino acids and has a mass of 36.7 Kilo Daltons. The molecule is heterodimeric - composed of two polypeptide chains. Alpha chain (92 amino acids long) is identical to LH (luteinizing hormone), FSH (follicle stimulating hormone) and TSH (thyroid stimulating hormone) while beta chain (145 amino acids long) is unique to the Human Chorionic Gonadotropin.

It was first recognized in the 1920s and first extracted from the human pituitary glands in 1958. Because urine of pregnant women is extremely rich with hCG some organizations still collect it today, extract hCG and use it in fertility clinics. Nowadays it is mostly produced and extracted from cultures of genetically modified cells using recombinant DNA technology.

The international measuring unit (IU) of hCG equals approximately 2.35×10-12 moles, or about 6×10-8 grams. Injectable HCG usually comes in vials of 5000 IU of freeze dried (lyophilized) powder form for reconstitution with sterile water for injection.

Table of Contents


Intended use of HCG



Human Chorionic Gonadotropin is primarily used as fertility aid. In women it triggers ovulation while in men it increases testosterone production and sperm count. HCG is also used in young boys when their testicles have not dropped down into the scrotum normally.

Because some cancers excrete HCG it can also be used as a tumor marker. A positive HCG test result in males (who are not otherwise injecting HCG) can be an indicator of testicular cancer or germ cell tumors.

HCG in PCT (post anabolic steroid cycle treatment)



In bodybuilding pharmacology HCG is one of the most misunderstood, misused and underutilized tools available. A bodybuilder who cares about his body functioning properly should never sacrifise his health for muscle gains. After every anabolic steroid cycle, the body's own testosterone production has to be fully restored.

When external androgenic anabolic steroids (AAS) are introduced into the male body the natural negative-feedback loop causes the body to shut down its own production of testosterone via shutdown of the hypothalamic-pituitary-gonadal axis (HPGA). In other words, when the body senses there is too much testosterone flowing around, it stops producing more of it.

High levels of anabolic steroids, which mimic the body's natural testosterone, cause the hypothalamus to stop its production of gonadotropin-releasing hormone (GnRH). Without GnRH, the pituitary gland stops making the luteinizing hormone (LH). Without LH, the testes shut down the body's production of testosterone.

The longer the testes are not getting the lutheinizing hormone, the more the cells within the testes known as leydig cells - (which are normally activated by LH) become desensitized. The testicular degeneration starts with reduction of leydig cell volume, followed by rapid reductions in intra testicular testosterone (ITT), peroxisomes, and Insulin-like factor 3 (INSL3). This is the reason why some men never completely recover after a long steroid cycle. In such cases the testes have stayed inactive for too long and have become permanently damaged and desensitized.

HCG during AAS cycle (Human Chorionic Gonadotropin during steroid cycle)



To prevent permanent shutdown of testosterone production a low dose of human chorionic gonadotropin (250IU 2 or 3 times per week) is used during the steroid cycle. One has to be careful and avoid dosing too high or too frequently as that can also desensitize the testes. The HCG dosage and the interval has to be just right to stimulate the leydig cells to produce the same amount of testosterone as they normally would. The saying more is better definitely does not apply to the use of HCG. Human chorionic gonadotropin has to be continued for as long as the steroids are active in the body and preferably 1-2 week beyond.

How to determine your HCG dosage for post cycle treatment (PCT)



The HCG dose in the post steroid cycle treatment depends on the severity of testosterone shutdown which was caused by steroids. If HCG was used during the cycle itself, the shutdown of endogenous testosterone would be less severe as compared to a long steroid cycle without HCG (stimulation of leydig cells in the testes).

To determine the proper dosage of HCG one has to consider these 4 decisive factors:

  • Duration of the steroid cycle: the longer the recent cycle, the more suppressed the leydig cells will be and the more Human Chorionic Gonadotropin the person will need to "shock" them back into action and make them start the natural testosterone production again.
  • Age of the user: generally older people require higher dosage of HCG to stimulate the leydig cells and testosterone production.
  • Accumulated damage to leydig cells: if the user has been cycling steroids for years and sometimes experienced incomplete testosterone recovery, it will be more difficult to recover each time. The more past damage has been accumulated to the leydig cells, the longer the user will have to stay on the HCG therapy followed by a longer pause between steroid cycles.
  • During the recent steroid cycle, did the user allow for full shutdown of the natural testosterone production or was there some kind of protection used to keep the leydig cells active (for example low dose HCG).


Generally the lowest useful dose for raising testosterone levels in males

Side effects of HCG (for males)



Side effects

Actual effects of Human Chorionic Gonadotropin (HCG) for men and women



These are the observable HCG effects for Men:
  • increase in testosterone production
  • improved libido
  • decrease in body fat
  • increased libido (with oral tablet form)
  • increased bone density and strength
  • improved mobility in tendons, ligaments and joints
  • increased endurance


How to mix and inject HCG





Where to buy HCG - Human Chorionic Gonadotropin?



Human chorionic gonadotropin is available for sale at 5kits (see the green button below)

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